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As open-and-shut cases go, Alzheimer’s disease should top
the list. The victim is clear. Suspects are in custody. Wherever neurons die
due to Alzheimer’s disease, a protein known as amyloid-beta is always found at
the scene of the crime, hanging around in large, tough gangs called plaques.
Parkinson’s and Huntington’s diseases; amyotrophic lateral sclerosis (which
goes by its initials ALS or the alias Lou Gehrig’s disease); and prion
diseases, such as scrapie in sheep, mad cow disease in
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